SEMAX is a synthetic ACTH-derived heptapeptide studied in neurotrophin signaling, neuronal stress responses, cerebral-ischemia models, learning, memory, and neurological gene-expression research. Intended strictly for controlled laboratory research.<\/p>\n","protected":false},"featured_media":536,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_tabt_what_is_it":"SEMAX is a synthetic research heptapeptide studied in neurotrophin signaling, neuronal stress responses, cognitive research, cerebral-ischemia models, and neurological gene-expression regulation.\r\nIt is derived from the ACTH(4\u20137) peptide fragment and includes an additional Pro-Gly-Pro sequence intended to increase the stability of the research molecule.\r\nPublished studies have examined SEMAX in relation to brain-derived neurotrophic factor, nerve growth factor, TrkB-related signaling, neuronal survival, hypoxic and ischemic stress, learning, memory, attention, and changes in brain gene expression.\r\nSEMAX remains an investigational research compound in the United States. Its long-term safety, approved human dosing, administration protocols, and therapeutic effectiveness have not been established for this research product.","_tabt_plain_english_explanation":"SEMAX is a small synthetic peptide based on part of a naturally occurring hormone-related peptide called ACTH.\r\nResearchers added a short Pro-Gly-Pro sequence to create a more stable research molecule without intending it to reproduce the full hormonal activity of ACTH.\r\nSEMAX is studied to understand how peptide signals may influence nerve-cell survival, growth-factor signaling, learning, memory, and cellular responses to low oxygen, reduced blood flow, or other neurological stress.\r\nA major area of research involves proteins called neurotrophins, including BDNF and NGF, which participate in neuronal survival, adaptation, and communication.\r\nThe available research does not establish that a commercial SEMAX research product safely improves memory, attention, recovery, or neurological function in humans.","_tabt_detailed_explanation":"SEMAX is a synthetic heptapeptide, meaning that it contains seven amino-acid residues.\r\nIts amino-acid sequence is:\r\nMet-Glu-His-Phe-Pro-Gly-Pro\r\nThe one-letter sequence abbreviation is:\r\nMEHFPGP\r\nThe first four amino acids correspond to the ACTH(4\u20137) fragment. The final three amino acids form the Pro-Gly-Pro sequence.\r\nACTH stands for adrenocorticotropic hormone. Full-length ACTH participates in adrenal and endocrine signaling, but SEMAX contains only a small fragment and should not be described as equivalent to full ACTH.\r\nThe Pro-Gly-Pro portion was added to produce a peptide with greater resistance to enzymatic breakdown than the shorter ACTH fragment alone.\r\nOne major area of SEMAX research involves neurotrophins.\r\nNeurotrophins are signaling proteins that participate in neuronal survival, development, adaptation, and synaptic plasticity. Two neurotrophins frequently examined in SEMAX studies are brain-derived neurotrophic factor, or BDNF, and nerve growth factor, or NGF.\r\nLaboratory and animal studies have reported changes in BDNF and NGF gene expression following experimental SEMAX exposure. Other studies have reported changes in BDNF protein levels and activation of TrkB, one of the principal receptors associated with BDNF signaling.\r\nThese responses have varied by brain region and by the amount of time that passed after exposure. A change observed in one tissue or at one time point should not be assumed to occur throughout the brain or in humans.\r\nSEMAX has also been studied in models of reduced oxygen and blood flow.\r\nHypoxia refers to inadequate oxygen availability. Ischemia refers to reduced blood supply to tissue. Both conditions can disrupt cellular energy production, increase excitotoxic stress, alter inflammatory signaling, and damage neurons.\r\nExperimental studies have examined whether SEMAX influences neuronal survival and gene-expression patterns during or after hypoxic and ischemic stress.\r\nResearch has reported changes in genes related to inflammation, immune signaling, vascular activity, neurotransmission, cellular stress, and neurotrophin pathways following experimental cerebral ischemia.\r\nThese findings do not establish that SEMAX prevents brain injury or treats stroke in humans.\r\nOther research has investigated learning, memory, attention, and synaptic plasticity. Some animal and limited human studies reported changes in cognitive or neurological measurements, but these findings remain preliminary and have not established a predictable cognitive-enhancement effect.\r\nSEMAX has also been examined in relation to cholinergic neurons. Cholinergic neurons use acetylcholine as a signaling molecule and participate in attention, memory, and other neurological processes.\r\nThe precise molecular mechanism of SEMAX has not been completely established.\r\nIts reported biological effects may involve multiple systems, including neurotrophin expression, receptor signaling, neurotransmitter-related pathways, inflammatory responses, and gene regulation.\r\nSEMAX should not be described as a proven nootropic, memory enhancer, stroke treatment, neuroprotective medication, antidepressant, anxiety treatment, ADHD treatment, or therapy for a neurological disease.\r\nIts human pharmacology, bioavailability, drug interactions, long-term safety, effective dose, and appropriate administration methods have not been established for this research product.","_tabt_research_snapshot":"Researchers study SEMAX in relation to neurotrophin signaling, neuronal survival, hypoxic stress, ischemic stress, learning, memory, attention, synaptic plasticity, and neurological gene-expression regulation.\r\nCell and animal studies have examined changes in brain-derived neurotrophic factor, commonly abbreviated as BDNF, nerve growth factor, commonly abbreviated as NGF, and TrkB-related signaling following experimental SEMAX exposure.\r\nResearch in rat brain tissue has reported time-dependent and region-specific changes in BDNF and NGF gene expression. Other studies have examined changes in BDNF protein levels and activation of its TrkB receptor.\r\nSEMAX has also been studied in experimental cerebral-ischemia models. Researchers have examined whether it changes the expression of genes involved in inflammatory signaling, vascular function, immune responses, neuronal survival, and tissue responses following reduced blood flow.\r\nAdditional studies have investigated learning, memory, attention, cholinergic neurons, glutamate-related cellular stress, and behavioral responses.\r\nSome clinical research has been reported in patients with ischemic stroke, but much of this evidence comes from a limited number of research groups and has not been broadly replicated in large, independently conducted international trials.\r\nThe available findings do not establish approved clinical effectiveness, long-term human safety, or an appropriate human-use protocol for this research product.","_tabt_possible_research_side_effects":"","_tabt_alternate_names":"","_tabt_common_research_areas":"\u2022 Neurotrophin signaling\r\n\u2022 Brain-derived neurotrophic factor research\r\n\u2022 Nerve growth factor research\r\n\u2022 TrkB-receptor signaling\r\n\u2022 Neuronal survival\r\n\u2022 Neuronal stress responses\r\n\u2022 Hypoxic-stress research\r\n\u2022 Cerebral-ischemia research models\r\n\u2022 Excitotoxic-stress research\r\n\u2022 Glutamate-related cellular stress\r\n\u2022 Learning and memory models\r\n\u2022 Attention-related research\r\n\u2022 Synaptic-plasticity research\r\n\u2022 Cognitive-process research\r\n\u2022 Neurological gene-expression regulation\r\n\u2022 Cholinergic-neuron research\r\n\u2022 Acetylcholine-related signaling\r\n\u2022 Inflammatory gene-expression research\r\n\u2022 Immune-response signaling\r\n\u2022 Vascular and endothelial response research\r\n\u2022 ACTH-fragment peptide research\r\n\u2022 Pro-Gly-Pro peptide research\r\n\u2022 Peptide stability and metabolism","_tabt_storage_instructions":"Do not enter a specific temperature unless your supplier documentation or batch-specific records confirm it.\r\nStore and handle according to the instructions provided with the applicable batch documentation.\r\nProtect the material from excessive heat, light, moisture, contamination, and conditions that could compromise product identity or research integrity.\r\nMaintain appropriate laboratory records for receipt, storage, handling, preparation, testing, and disposal.\r\nFor laboratory research only.","_tabt_research_disclaimer":"FOR RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION.\r\nThis product is intended exclusively for controlled laboratory research. It is not intended for diagnostic, therapeutic, neurological, psychiatric, veterinary, household, food, cosmetic, wellness, cognitive-enhancement, or performance-enhancement use.\r\nIt is not intended to diagnose, treat, cure, mitigate, or prevent stroke, brain injury, cognitive impairment, memory loss, attention disorders, depression, anxiety, neurodegenerative disease, or any other disease or medical condition.\r\nPublished SEMAX findings include cell experiments, animal models, cerebral-ischemia models, mechanistic research, and limited clinical studies. These findings do not establish broad clinical effectiveness, long-term human safety, approved dosing, administration protocols, or predictable outcomes.\r\nChanges in BDNF, NGF, TrkB signaling, gene expression, learning, memory, or neuronal survival observed in experimental models do not establish equivalent effects in humans.\r\nThe purchaser is responsible for lawful acquisition, handling, storage, documentation, research use, and disposal.","_tabt_live_product_label_enabled":"no","_tabt_live_product_label_show_cas":"","_tabt_live_product_label_show_formula":"","_tabt_live_product_label_show_mass":"","_tabt_research_evidence_level":"","_tabt_research_evidence_summary":"","_tabt_molecular_composition":"","_tabt_molecular_chain_length":"","_tabt_molecular_cas_number":"","_tabt_molecular_formula":"","_tabt_molecular_mass":"","_tabt_molecular_modifications":"","_tabt_molecular_targets":"","_tabt_molecular_identity_notes":"","_tabt_scientific_references":""},"product_brand":[],"product_cat":[22],"product_tag":[],"tabt_research_category":[23],"class_list":["post-205","product","type-product","status-publish","has-post-thumbnail","product_cat-cognitive-neurological-research","tabt_research_category-cognitive-neurological-research","desktop-align-left","tablet-align-left","mobile-align-left","first","instock","shipping-taxable","purchasable","product-type-variable"],"yoast_head":"\n