MOTS-c is a mitochondrial-derived research peptide studied for its role in cellular energy signaling, metabolic stress responses, glucose metabolism, and communication between mitochondria and the cell nucleus. Intended strictly for controlled laboratory research.<\/p>\n","protected":false},"featured_media":524,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_tabt_what_is_it":"MOTS-c is a mitochondrial-derived research peptide studied for its role in cellular energy sensing, metabolic signaling, and communication between mitochondria and the cell nucleus.\r\nMOTS-c is a naturally occurring 16-amino-acid peptide encoded within the mitochondrial 12S ribosomal RNA region. Research has examined how it may help cells respond to changing energy conditions, nutrient availability, metabolic stress, and physical activity.\r\nMost research involving externally administered MOTS-c has been conducted in laboratory and animal models. Human clinical effects, safety, dosing, and therapeutic applications have not been established.","_tabt_plain_english_explanation":"MOTS-c is a small signaling peptide produced from genetic information inside the mitochondria.\r\nMitochondria are best known for helping cells manage energy, but they also send signals that affect how the rest of the cell responds to stress and changes in nutrient availability.\r\nResearchers study MOTS-c to understand how mitochondrial signals may influence cellular energy use, glucose metabolism, stress responses, skeletal-muscle activity, and communication with the cell nucleus.","_tabt_detailed_explanation":"MOTS-c stands for mitochondrial open reading frame of the 12S rRNA type-c.\r\nIt is a 16-amino-acid peptide encoded by mitochondrial DNA. This distinguishes it from most peptides and proteins, which are encoded by DNA inside the cell nucleus.\r\nMitochondria are involved in cellular energy production, but they also act as signaling centers. They can communicate information about energy availability, nutrient conditions, and cellular stress to other parts of the cell.\r\nMOTS-c is studied as one of these mitochondrial-derived signaling molecules.\r\nLaboratory research suggests that MOTS-c can influence folate and purine metabolism. These changes may increase cellular levels of an AMP-related molecule known as AICAR, which is associated with activation of AMP-activated protein kinase, commonly abbreviated as AMPK.\r\nAMPK is an enzyme that helps cells detect changes in energy availability and coordinate metabolic responses. Researchers therefore study MOTS-c in connection with cellular energy sensing, glucose utilization, lipid metabolism, and adaptation to metabolic stress.\r\nUnder certain experimental stress conditions, MOTS-c has also been observed moving from the mitochondria-related cellular environment into the nucleus. In the nucleus, it may influence the expression of genes involved in stress resistance and cellular adaptation.\r\nResearchers have also examined MOTS-c in skeletal muscle and exercise-related studies. Naturally occurring MOTS-c levels have been observed to change following exercise in a small human study, while experiments in mice examined physical capacity and age-related metabolic changes.\r\n\r\nThese findings remain investigational. Results from cells, animals, or measurements of naturally occurring MOTS-c cannot be used to establish the safety, effectiveness, or appropriate use of an externally supplied MOTS-c research product in humans.","_tabt_research_snapshot":"Researchers study MOTS-c to better understand mitochondrial signaling, cellular energy regulation, glucose utilization, metabolic stress responses, skeletal-muscle metabolism, and mitochondrial-to-nuclear communication.\r\nPublished laboratory and preclinical studies have examined MOTS-c in relation to AMPK-related energy sensing, folate and purine metabolism, AICAR-associated signaling, insulin sensitivity, glucose metabolism, physical activity, and cellular adaptation.\r\nResearch has also observed MOTS-c moving into the cell nucleus during metabolic stress. This process has been studied for its possible role in regulating nuclear genes involved in stress responses and cellular balance.\r\nHuman studies have examined naturally occurring MOTS-c levels in blood and skeletal muscle, including changes associated with exercise. These studies do not establish that an externally supplied MOTS-c product produces the same effects in humans.","_tabt_possible_research_side_effects":"","_tabt_alternate_names":"","_tabt_common_research_areas":"\u2022 Mitochondrial signaling\r\n\u2022 Cellular energy sensing\r\n\u2022 AMPK-related signaling\r\n\u2022 Mitochondrial-to-nuclear communication\r\n\u2022 Metabolic stress responses\r\n\u2022 Glucose utilization and glucose metabolism\r\n\u2022 Insulin-signaling research\r\n\u2022 Folate and purine metabolism\r\n\u2022 AICAR-associated cellular signaling\r\n\u2022 Skeletal-muscle metabolism\r\n\u2022 Exercise-related cellular responses\r\n\u2022 Lipid and metabolic regulation\r\n\u2022 Oxidative-stress response pathways\r\n\u2022 Nuclear gene-expression regulation\r\n\u2022 Aging-related metabolic research","_tabt_storage_instructions":"Do not enter a specific temperature unless your supplier documentation or batch-specific records confirm it.\r\nStore and handle according to the instructions provided with the applicable batch documentation.\r\nProtect the material from excessive heat, light, moisture, and contamination. Maintain appropriate laboratory records for receipt, storage, handling, and disposal.\r\nFor laboratory research only.","_tabt_research_disclaimer":"FOR RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION.\r\n\r\nThis product is intended exclusively for controlled laboratory research. It is not intended for diagnostic, therapeutic, veterinary, household, food, cosmetic, or performance-enhancement use.\r\nIt is not intended to diagnose, treat, cure, mitigate, or prevent any disease or medical condition.\r\nPublished findings involving MOTS-c are primarily based on laboratory, animal, observational, or other early-stage research. These findings do not establish approved clinical uses, human safety, effectiveness, dosing, or administration protocols.\r\nThe purchaser is responsible for lawful acquisition, handling, storage, documentation, research use, and disposal.","_tabt_live_product_label_enabled":"no","_tabt_live_product_label_show_cas":"yes","_tabt_live_product_label_show_formula":"yes","_tabt_live_product_label_show_mass":"yes","_tabt_research_evidence_level":"","_tabt_research_evidence_summary":"","_tabt_molecular_composition":"","_tabt_molecular_chain_length":"","_tabt_molecular_cas_number":"","_tabt_molecular_formula":"","_tabt_molecular_mass":"","_tabt_molecular_modifications":"","_tabt_molecular_targets":"","_tabt_molecular_identity_notes":"","_tabt_scientific_references":""},"product_brand":[],"product_cat":[22,20],"product_tag":[],"tabt_research_category":[23,25],"class_list":["post-210","product","type-product","status-publish","has-post-thumbnail","product_cat-cognitive-neurological-research","product_cat-metabolic-research","tabt_research_category-cognitive-neurological-research","tabt_research_category-metabolic-research","desktop-align-left","tablet-align-left","mobile-align-left","first","instock","shipping-taxable","purchasable","product-type-variable"],"yoast_head":"\n