TRUE AXIS BIO
Semax
- CAS Number
- 80714-61-0
- Molecular Formula
- C37H51N9O10S
- Molecular Weight
- 813.9 g/mol
FOR RESEARCH USE ONLYNOT FOR HUMAN CONSUMPTION
TRUE AXIS BIO
Selank
- CAS Number
- 129954-34-3
- Molecular Formula
- C33H57N11O9
- Molecular Weight
- 751.9 g/mol
FOR RESEARCH USE ONLYNOT FOR HUMAN CONSUMPTION
Selank
Selank is a synthetic heptapeptide studied in GABA-related neurotransmission, stress-response signaling, cognition, and neuroimmune research. Intended strictly for controlled laboratory research.
For Research Use Only (RUO). Not for human or animal consumption.
Not intended to diagnose, treat, cure, or prevent any disease.
Purchaser must meet all applicable age requirements.
SKU: TAB-SELANK
Plain-English Summary
Research Overview
- What It Is
- Selank is a synthetic research peptide studied for its potential effects on neurotransmission, stress-response signaling, cognitive processes, and immune-related pathways.
It is a seven-amino-acid peptide derived from the naturally occurring immunomodulatory peptide tuftsin.
Published research has examined Selank in relation to GABA-associated signaling, gene expression involved in neurotransmission, learning and memory, brain-derived neurotrophic factor, cytokine regulation, and anxiety-related behavior.
Selank remains an investigational research compound. Human safety, long-term effects, approved dosing, and therapeutic effectiveness have not been established for this research product. - Explanation
- Selank is a small synthetic peptide modeled after part of a naturally occurring immune-signaling peptide called tuftsin.
Researchers study Selank to understand how peptide signals may influence communication between nerve cells, responses to stress, learning and memory, and interactions between the nervous and immune systems.
One major area of research involves GABA, a neurotransmitter that helps regulate nerve-cell activity.
The available research is early and does not establish that a commercial Selank research product is safe or effective for treating anxiety, improving memory, or producing another clinical outcome. - Why It’s Researched
- Researchers study Selank in relation to GABA-associated neurotransmission, stress responses, cognitive processes, learning and memory, neurotrophic signaling, cytokine regulation, and neuroimmune communication.
Cell-based research has examined changes in the expression of genes involved in neurotransmission following exposure to Selank. Some findings suggest that its molecular effects may involve modulation of the GABAergic system rather than direct activity identical to GABA itself.
Animal studies have investigated Selank in models of anxiety-related behavior, learning, memory, stress, and changes in brain-derived neurotrophic factor, commonly abbreviated as BDNF.
Small clinical studies have examined Selank in patients with anxiety-related conditions and have evaluated psychological measures, cytokine responses, and comparisons with established medications.
These studies have important limitations, including small sample sizes, limited independent replication, older research methods, and publication in a relatively narrow group of research centers.
The available findings do not establish approved clinical use, long-term safety, or an appropriate human-use protocol for this research product. - Storage Instructions
- Do not enter a specific temperature unless your supplier documentation or batch-specific records confirm it. Store and handle according to the instructions provided with the applicable batch documentation. Protect the material from excessive heat, light, moisture, contamination, and conditions that could compromise product identity or research integrity. Maintain appropriate laboratory records for receipt, storage, handling, preparation, testing, and disposal. For laboratory research only.
Once reconstituted, store at the verified temperature specified for the exact product or formulation when such guidance is available.
Product-Specific Information
Scientific Details
- Scientific Context
- Selank is a synthetic heptapeptide, meaning that it contains seven amino-acid residues.
Its amino-acid sequence is:
Thr-Lys-Pro-Arg-Pro-Gly-Pro
This sequence is commonly abbreviated as:
TKPRPGP
Selank was developed from tuftsin, a naturally occurring tetrapeptide involved in immune-cell signaling. Selank contains the tuftsin sequence with an additional Pro-Gly-Pro segment.
Because of this structure, researchers have investigated Selank in both nervous-system and immune-related models.
One major research area involves the GABAergic system.
GABA, or gamma-aminobutyric acid, is an inhibitory neurotransmitter that helps regulate the activity of nerve cells. Laboratory studies have examined whether Selank changes GABA binding, GABA-receptor activity, or the expression of genes associated with GABA-related neurotransmission.
The results suggest that Selank does not act as a simple replacement for GABA. Its reported effects appear more complex and may involve modulation of receptor interactions or broader changes in neuronal signaling.
Research has also examined Selank in relation to monoamine neurotransmitters, including serotonin-related metabolism. These findings are primarily from animal experiments and do not establish a predictable effect in humans.
Animal studies have investigated possible effects on learning and memory. Some experiments reported changes in task performance, particularly in animals with initially weaker learning performance.
Other studies have examined BDNF, or brain-derived neurotrophic factor. BDNF is a signaling protein involved in neuronal growth, adaptation, and plasticity. Research in rats reported changes in hippocampal BDNF expression after experimental Selank exposure.
Selank has also been studied as a possible link between neurological and immune signaling. Clinical and animal research has examined cytokines and the balance of immune-related signaling molecules under stress or anxiety-related conditions.
Small clinical studies reported changes in anxiety-related scores and other measurements, but these findings do not constitute broad confirmation of effectiveness. The studies were limited in size, geography, replication, and overall evidence quality.
Selank should not be described as a proven treatment for anxiety, depression, cognitive impairment, post-traumatic stress, or another neurological or psychiatric condition.
It also should not be presented as a guaranteed nootropic, memory enhancer, mood enhancer, or replacement for an approved medication.
Selank remains investigational. Approved human dosing, administration methods, long-term safety, drug interactions, and therapeutic indications have not been established for this research product.
Mechanism Snapshot
Targets & Pathways
- Common Research Areas
- • GABA-associated neurotransmission
• GABA-receptor interaction research
• Gene expression involved in neurotransmission
• Stress-response signaling
• Anxiety-related behavioral models
• Learning and memory research
• Cognitive-process research
• Brain-derived neurotrophic factor research
• Hippocampal signaling
• Neuronal plasticity research
• Monoamine neurotransmitter metabolism
• Serotonin-related research
• Enkephalin metabolism
• Neuroimmune communication
• Cytokine regulation
• Th1 and Th2 cytokine-balance research
• Tuftsin-derived peptide research
• Comparison with other neurological research peptides
• Peptide stability and metabolism
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