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Selank
- CAS Number
- 129954-34-3
- Molecular Formula
- C33H57N11O9
- Molecular Weight
- 751.9 g/mol
FOR RESEARCH USE ONLYNOT FOR HUMAN CONSUMPTION
TRUE AXIS BIO
Semax
- CAS Number
- 80714-61-0
- Molecular Formula
- C37H51N9O10S
- Molecular Weight
- 813.9 g/mol
FOR RESEARCH USE ONLYNOT FOR HUMAN CONSUMPTION
Semax
SEMAX is a synthetic ACTH-derived heptapeptide studied in neurotrophin signaling, neuronal stress responses, cerebral-ischemia models, learning, memory, and neurological gene-expression research. Intended strictly for controlled laboratory research.
For Research Use Only (RUO). Not for human or animal consumption.
Not intended to diagnose, treat, cure, or prevent any disease.
Purchaser must meet all applicable age requirements.
SKU: TAB-SEMAX
Plain-English Summary
Research Overview
- What It Is
- SEMAX is a synthetic research heptapeptide studied in neurotrophin signaling, neuronal stress responses, cognitive research, cerebral-ischemia models, and neurological gene-expression regulation.
It is derived from the ACTH(4–7) peptide fragment and includes an additional Pro-Gly-Pro sequence intended to increase the stability of the research molecule.
Published studies have examined SEMAX in relation to brain-derived neurotrophic factor, nerve growth factor, TrkB-related signaling, neuronal survival, hypoxic and ischemic stress, learning, memory, attention, and changes in brain gene expression.
SEMAX remains an investigational research compound in the United States. Its long-term safety, approved human dosing, administration protocols, and therapeutic effectiveness have not been established for this research product. - Explanation
- SEMAX is a small synthetic peptide based on part of a naturally occurring hormone-related peptide called ACTH.
Researchers added a short Pro-Gly-Pro sequence to create a more stable research molecule without intending it to reproduce the full hormonal activity of ACTH.
SEMAX is studied to understand how peptide signals may influence nerve-cell survival, growth-factor signaling, learning, memory, and cellular responses to low oxygen, reduced blood flow, or other neurological stress.
A major area of research involves proteins called neurotrophins, including BDNF and NGF, which participate in neuronal survival, adaptation, and communication.
The available research does not establish that a commercial SEMAX research product safely improves memory, attention, recovery, or neurological function in humans. - Why It’s Researched
- Researchers study SEMAX in relation to neurotrophin signaling, neuronal survival, hypoxic stress, ischemic stress, learning, memory, attention, synaptic plasticity, and neurological gene-expression regulation.
Cell and animal studies have examined changes in brain-derived neurotrophic factor, commonly abbreviated as BDNF, nerve growth factor, commonly abbreviated as NGF, and TrkB-related signaling following experimental SEMAX exposure.
Research in rat brain tissue has reported time-dependent and region-specific changes in BDNF and NGF gene expression. Other studies have examined changes in BDNF protein levels and activation of its TrkB receptor.
SEMAX has also been studied in experimental cerebral-ischemia models. Researchers have examined whether it changes the expression of genes involved in inflammatory signaling, vascular function, immune responses, neuronal survival, and tissue responses following reduced blood flow.
Additional studies have investigated learning, memory, attention, cholinergic neurons, glutamate-related cellular stress, and behavioral responses.
Some clinical research has been reported in patients with ischemic stroke, but much of this evidence comes from a limited number of research groups and has not been broadly replicated in large, independently conducted international trials.
The available findings do not establish approved clinical effectiveness, long-term human safety, or an appropriate human-use protocol for this research product. - Storage Instructions
- Do not enter a specific temperature unless your supplier documentation or batch-specific records confirm it. Store and handle according to the instructions provided with the applicable batch documentation. Protect the material from excessive heat, light, moisture, contamination, and conditions that could compromise product identity or research integrity. Maintain appropriate laboratory records for receipt, storage, handling, preparation, testing, and disposal. For laboratory research only.
Once reconstituted, store at the verified temperature specified for the exact product or formulation when such guidance is available.
Product-Specific Information
Scientific Details
- Scientific Context
- SEMAX is a synthetic heptapeptide, meaning that it contains seven amino-acid residues.
Its amino-acid sequence is:
Met-Glu-His-Phe-Pro-Gly-Pro
The one-letter sequence abbreviation is:
MEHFPGP
The first four amino acids correspond to the ACTH(4–7) fragment. The final three amino acids form the Pro-Gly-Pro sequence.
ACTH stands for adrenocorticotropic hormone. Full-length ACTH participates in adrenal and endocrine signaling, but SEMAX contains only a small fragment and should not be described as equivalent to full ACTH.
The Pro-Gly-Pro portion was added to produce a peptide with greater resistance to enzymatic breakdown than the shorter ACTH fragment alone.
One major area of SEMAX research involves neurotrophins.
Neurotrophins are signaling proteins that participate in neuronal survival, development, adaptation, and synaptic plasticity. Two neurotrophins frequently examined in SEMAX studies are brain-derived neurotrophic factor, or BDNF, and nerve growth factor, or NGF.
Laboratory and animal studies have reported changes in BDNF and NGF gene expression following experimental SEMAX exposure. Other studies have reported changes in BDNF protein levels and activation of TrkB, one of the principal receptors associated with BDNF signaling.
These responses have varied by brain region and by the amount of time that passed after exposure. A change observed in one tissue or at one time point should not be assumed to occur throughout the brain or in humans.
SEMAX has also been studied in models of reduced oxygen and blood flow.
Hypoxia refers to inadequate oxygen availability. Ischemia refers to reduced blood supply to tissue. Both conditions can disrupt cellular energy production, increase excitotoxic stress, alter inflammatory signaling, and damage neurons.
Experimental studies have examined whether SEMAX influences neuronal survival and gene-expression patterns during or after hypoxic and ischemic stress.
Research has reported changes in genes related to inflammation, immune signaling, vascular activity, neurotransmission, cellular stress, and neurotrophin pathways following experimental cerebral ischemia.
These findings do not establish that SEMAX prevents brain injury or treats stroke in humans.
Other research has investigated learning, memory, attention, and synaptic plasticity. Some animal and limited human studies reported changes in cognitive or neurological measurements, but these findings remain preliminary and have not established a predictable cognitive-enhancement effect.
SEMAX has also been examined in relation to cholinergic neurons. Cholinergic neurons use acetylcholine as a signaling molecule and participate in attention, memory, and other neurological processes.
The precise molecular mechanism of SEMAX has not been completely established.
Its reported biological effects may involve multiple systems, including neurotrophin expression, receptor signaling, neurotransmitter-related pathways, inflammatory responses, and gene regulation.
SEMAX should not be described as a proven nootropic, memory enhancer, stroke treatment, neuroprotective medication, antidepressant, anxiety treatment, ADHD treatment, or therapy for a neurological disease.
Its human pharmacology, bioavailability, drug interactions, long-term safety, effective dose, and appropriate administration methods have not been established for this research product.
Mechanism Snapshot
Targets & Pathways
- Common Research Areas
- • Neurotrophin signaling
• Brain-derived neurotrophic factor research
• Nerve growth factor research
• TrkB-receptor signaling
• Neuronal survival
• Neuronal stress responses
• Hypoxic-stress research
• Cerebral-ischemia research models
• Excitotoxic-stress research
• Glutamate-related cellular stress
• Learning and memory models
• Attention-related research
• Synaptic-plasticity research
• Cognitive-process research
• Neurological gene-expression regulation
• Cholinergic-neuron research
• Acetylcholine-related signaling
• Inflammatory gene-expression research
• Immune-response signaling
• Vascular and endothelial response research
• ACTH-fragment peptide research
• Pro-Gly-Pro peptide research
• Peptide stability and metabolism
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